Keyur P. Biology...Science Rasmussens Encephalitis The Human Immune Sy

Keyur P. Biology...Science Rasmussen's Encephalitis The human immune system is an amazing system that is constantly on the alert protecting us from sicknesses. Thousands of white blood cells travel in our circulatory system destroying all foreign substances that could cause harm to our body or to any of the millions of processes going on inside. Now imagine a condition where this awesome system turns against the most complex organ in the human body, the brain. Deadly as it is, this condition is known as Rasmussen's encephalitis. The meaningful research on Rasmussen's encephalitis was begun (unintentionally) by Scott Rogers and Lorise Gahring, two neurologists, who were at the time measuring the distribution of glutamate receptors in the brain. Later on when more provocative information was found they enlisted the help of James McNamara and Ian Andrews, epilepsy experts at Duke University Medical Center. The details on Rasmussen's encephalitis were very bleak at the time when the men began their research. All that was known is that Rasmussen's encephalitis was a degenerative disease of the brain that caused seizures, hemiparesis, and dementia normally in the first ten years of life. The seizures that were caused by Rasmussen's encephalitis were unstoppable by normal anti-seizure drugs used conventionally. What the worst part of the disease was that the pathogenesis for it were not known and even worse was how it developed. The first clue was delivered when Rogers and Gahring were trying to register the distribution of the glutamate receptors using antibodies, that tag on to the receptor itself. The proteins that make up the glutamate receptors(GluR) are only found inside the blood brain barrier(BBB). Glutamate and a few related amino acids are the dominant form of excitatory neurotransmitter in the central nervous system of mammals. If one of these GluRs happens to wander into the actual bloodstream, that is outside the BBB, it would be considered an outsider and destroyed immediately. So if these GluRs were put into the normal blood stream then the immune system would produce antibodies which could then be used in the searching for the glutamate receptors. In order to test this theory the researchers injected the GluRs into the blood stream of a normal healthy rabbit hoping to produce good results. At this point the experiment took a dramatic turn, after receiving a few doses of the protein two of the three rabbits began to twitch, as though they were suffering the pain of an epileptic seizure. Now the help of McNamara and Andrews was enlisted. When McNamara and Andrews examined the brain tissue of the rabbits, they saw what seemed to be a familiar inflammatory pattern, clumps of immune cells all around blood vessels. This description exactly matched the description of persons suffering from Rasmussen's encephalitis, moreover something as this would never be found in a healthy brain. A healthy br ain has its blood capillaries enclosed in the BBB membrane, so such a case as the one mentioned above would not be possible. As protective as the BBB is, it can be breached by something like a head injury. What was happening was that the antibodies which were out to get the GluR proteins were somehow finding a way into the brain and directing an attack towards all GluR receptor proteins in the brain itself. After some more examinations Rogers and McNamara decided that these attacks were the cause of the seizures that are often experienced by sufferers of Ramussen's encephalitis. Then if the case is of antibodies in the bloodstream, than sufferers of Ramussen's encephalitis should have them in their bloodstream and healthy normal peoples shouldn't. When this was actually tested the results were positive that Rasmussen sufferers did have these antibodies in their bloodstreams and healthy people did not. These were not only the right kind of antibodies but, the very antibodies that caused the seizures in people and rabbits. Thus when these antibodies were removed by plasma exchange(PEX) it caused a temporary relief from the seizures but soon the body starts making more antibodies of the type and the seizures start once again. After all the examinations two questions remained, why does the body mount an immune response against one of its own brain proteins,

The eNotes Blog Louise Erdrich Wins 2012 National BookAward

Louise Erdrich Wins 2012 National BookAward It was a good morning for author Louise Erdrich, as she was announced the recipient of 2012s National Book Award for her novel  The Round House.   Like much of Erdrichs other work (Love Medicine, The Red Convertible),  The Round House  concerns the life of a Native American family in crisis and a culture in jeopardy. The Round House  is the story of a crime. Geraldine Coutts, an Ojibwe woman living on a reservation, is attacked. Neither her husband, Bazil, nor her thirteen-year-old son, Joe, were present when she was assaulted. Geraldine will not tell them who did it or or why; nor will she tell the police. Although Joe desperately tries to get her to tell him, or anyone, what happened, Geraldine refuses. She will not even leave her bed. Essentially motherless, Joe is left to fend for himself, although he is far from ready for the weight of adult  responsibilities. Joes father, Bazil, is a tribal judge but justice moves too slowly for the teenager. He begins his own investigation which ultimately leads him to the Round House, a sacred place of worship where, eventually, secrets are revealed. Runners Up: Speculation about who would win this year was a bit more contentious than in years past, as there were many strong contenders, both critically and popularly. One of those considered a good bet was Junot Diazs  This is How You Lose Her.   Ã‚  Nine stories intertwine, but at the center is Yunior, a young hardhead whose longing for love is equaled only by his recklessnessand by the extraordinary women he loves and loses: artistic Alma; the aging Miss Lora; Magdalena, who thinks all Dominican men are cheaters; and the love of his life, whose heartbreak ultimately becomes his own. While Diaz is undoubtedly disappointed by his loss, he certainly has a lot to console him, as this year, the 44-year-old writer was given a MacArthur Fellowship. You can listen to an interview with Diaz about that prestigious appointment here. A long shot, but a strong critical and popular favorite was not a novel but a memoir.  The Boy Kings of Texas  is about the experiences of Domingo Martinez as he grew up in the border town of Brownsville, Texas. The book is Partly a reflection on the culture of machismo and partly an exploration of the author’s boyhood spent in his sister’s hand-me-down clothes,  The Boy Kings of Texas  delves into the enduring and complex bond between Martinez and his deeply flawed but fiercely protective older brother, Daniel, and features a cast of memorable characters. Charming, painful and enlightening, this book examines the traumas and pleasures of growing up in South Texas and the often terrible consequences when two very different cultures collide on the banks  of a dying river. One of the stories from the work was featured in a must-listen segment of last weeks episode of  This American Life.  You can listen to the full episode here, or queue it up to Act III to hear Martinez read Mimis in the Middle. In another episode of the autobiography, the 13-year-old Domingo is a helpless passenger in his mothers car as she and Domingo follow his father, who is driving a truck full of marijuana, all of them hoping they do not get caught. Christmas is coming up, you know. How about adding one of these, or all three, to your wish list?

Living With a Cardiac Pacemaker Essay Example | Topics and Well Written Essays - 750 words

Living With a Cardiac Pacemaker - Essay Example From this discussion it is clear that the device ensures that individuals have more energy. In addition, they experience less shortness of breath. The use of a pacemaker has many benefits: it normalizes the heart rhythm of the person and improves their quality of life, among other things. Physicians recommend demand pacemakers in a variety of cases based on the cardiac problems. As a result, the potential benefits may vary from one person to another. The device is usually implanted inside the upper chest. The primary objective of using the device is to monitor the heart rate. The device transmits an electrical signal when necessary in order to stabilize an irregular heartbeat. However, the device is not a cure. Instead, it merely serves to prolong the life of the patient.This study highlights that  Jim has a right to be concerned about the implications of using the device. He has to determine if the product will have a positive or negative impact on his health. As a truck driver, h e should be concerned about the impact of electric or gas powered appliances on his health. In addition, he cannot use some tools without undermining his health. The device should not be in close contact with magnetic or electromagnetic fields. However, the couple should not alter their travel plans. He can still engage in swimming and gardening. His participation in these physical activities should be closely monitored.

Analysis of Earned Income Tax Credit Assignment Example | Topics and Well Written Essays - 500 words

Analysis of Earned Income Tax Credit - Assignment Example Various states have hence established their highly effective EITCs so as to act as the direct supplements to the federal credit. Responsible for a number of societal transformations: The main purpose of the chartbook is the aspect of taking the best possible descriptive data based on the early childhood growth and the related social elements while making them accessible to all the low-income earners. Offers support to better and comprehensive federal plans: The EITC as well as the CTC (Child Tax Credit), which entirely flows to the low- and average-income families each and every year, tend to provide a wide range of work, educational, health, and income benefits to the recipients.   External Macro-intervention is a broad concept that tends to determine rippling up of the organization’s economic and policy levels. It generally means the external assessment of all the policy interventions and instruments that impact on the dynamics of conflicting elements such as humanitarian interventions, military interventions, and developmental interventions, among others. It refers to the core of skills and knowledge with regards to the social perspective. It assists while making some assessments and decisions regarding the appropriate conditional client intervention. It majorly involves individuals, communities, and groups experiencing the vulnerability and disadvantages that are characterized by some sort of disparities.

Human Resource Management Essay Example | Topics and Well Written Essays - 1500 words - 15

Human Resource Management - Essay Example The company has a total of 37 aircraft, and more than 9000 employees. Annually, Virgin Atlantic serves 4.5M passengers to major cities globally. The company has grown rapidly. Now serves 31 destinations worldwide, and has a made its mark in pioneering many innovative services packages and has gone ahead to set new guidelines in its industry. The company has continued expanding with the same vigour it began. Although the company has a massive growth streak, Virgin Atlantic is considered customer oriented, with more emphasis on their money value and has offered uniqueness in service delivery and high quality service. The enterprise faces an aggressive competitor in the airline business, British Airways. Virgin Atlantic is one of the most successful business venture taken up by the vast Virgin Group of companies. This report seeks to address in detail, the aspects of some of the concepts and human resources strategies which Virgin Atlantic airways has implemented to achieve such success in employee satisfaction and subsequently in their business field. They seem to have perfected all the five models of Human Resource. These include teamwork, organization culture, performance management, learning, development, and leadership. This report however focuses on how two practises have help improve their employee and system as well as critically analyzing Virgin Atlantic on the these bases of the theories. Virgin Atlantic is passionate about exploration, taking risks, challenging conventions and looking for solutions and that made it the company it is presently. That is how it has developed its perfect brand. An innovator established the brand and made it such a perfect setting to developed ones career. Virgin Atlantic has taken the creativity and innovation seriously and it is considered a place where great service is of concern. The company establishes a comprehensive framework for the career of the employees from the very beginning.

Cultural Research of Nayar of India

Cultural Research of Nayar of India This research paper provides insights into the Political Organization, Gender Relations, and Beliefs and Values of the agrarian state and cultural practices of the Nayar people of southwestern India. By understanding the Nayar culture, people may better understand and appreciate cultural differences between the Nayar culture and that of their own. In the essay, Some Aspects of Nayar Life Panikkar (1918) states, The Nayars are at present an essentially agricultural population. The vast majority of them are peasant proprietors owning small farms. Rice and coco-nuts are the chief things cultivated, though in North Malabar pepper and card oman have also their share (p.285). It should also be noted that states are much more complex and stratified than chiefdoms, so it is not feasible to rely solely on kinship as a recruitment method. In state systems, land ownership and occupation are at least as important as kinship as a system of organization; the state itself becomes a key institution of organization. (Nowak, et al., 2010, ch.7.8, n. p.). Of particular interest is the fact that the Nayar as with other caste societies, marry within their own caste. While this similarity with other endogamous societies helps to preserve the class of people, the Nayar marriage practices vary considerably from other agrarian states and caste for which I explain later. Political Organization The political system among the Nayar people has as with most cultures that have been the target of colonialism and capitalism, seen considerable change over last several hundred years. Much of the former kinship, matrilineal and political structures and systems of the Nayar culture have all but vanished. Kathleen Gough (1952), stated that Later in the nineteenth century, more deep-rooted economic changes took place, and these have increased in momentum until all the traditional groupings of caste, village and lineage are dis-integrating (p. 79). The political and economic influence during the later part of 19th century by the British probably had the most notable impact on the Nayar people. European military forces and government structures as well as the introduction of machines played a significant role in the changing political and economic structures and systems as well as building of permanent roads and railroads. The introduction of new trading opportunities, realignment of jobs, tighter controls to ensure peace, increased use of monetary currency, and broader reaching governmental jurisdiction across caste and villages played a vital role in redesigning the Nayar culture and politics as well. Evidence of this breaking down of prior systems has been described as The expansion of trade, the introduction of new technological devices, and the opening up of new occupations, produce new economic classes between which there is mobility, and which to some extent cut across the affiliations and ranking of caste. (Gough, 1952, p. 81). Through the elimination of caste ranking, socioeconomic and sociopolitical class rankings no longer limit Nayar people from changing class levels and limits have become more aligned with performance and education. With the introduction of formal government, monetary systems, increased import and export as well as technological advances, the former Nayar methods of controlling the distribution of wealth, food and other trade labor as well as class distinctions have resulted in a more capitalistic society. Along with these changes, the Nayar people are increasingly integrating practices common in more advanced capitalistic and socialistic society forms of government, business, and family relationships. Gender Relations Anthropologists studying the Nayar society of southwestern India continue to struggle with defining certain aspects of gender relations in a western context. One such area of significant interest and difficulty is in contrasting Nayar marriage with marriage in western society and terms. While marriage may be seen by many as a cultural universal even in consideration of variations such as polygamy, the Nayar marriage purpose and experience is quite different from marriages in most other societies. Perhaps, such significant differences would be more understandable if a different term other than marriage was used to represent Nayar marriage. One example of the differences in Nayar marriages as stated by Miriam Koktvedgaard (2008) was that The Nayar of India practiced a form of non-fraternal polyandry in which several men were simultaneously the husbands of one wife. Usually only the first husband underwent a ritual marriage with the woman before she entered puberty (p.11). This cultural practice appears to be an extraordinary characteristic of the Nayar unlike most other marriage constructs. Not so much perhaps as a woman having multiple simultaneous husbands although rare, but having ritual marriages with a woman that has not reached puberty. In order to further elaborate on the marriage of girls that have not yet reach puberty, I should explain that Before a girl reaches puberty, a Nayar girl is married to a man as a rite of passage. The man she marries has no rights to the girl, and she has no obligation to him. When she is older, the girl is allowed to enter into other marriages and have children with those husbands. (Nowak, et al., 2010, ch 7.8, n.p.) Anthropologist suspect that by maintain a loosely committed marriage relationship with both men and women being sexually active with other mates or spouses, it allows men to stay away for long periods of time with little affect on the family system. Another characteristic of the Nayar gender relationship was with regard to the definition of the domestic unit or nuclear family in that The central Nayar domestic unit consisted of a mother, her daughters and their children; husbands and wife did not set up house together (Koktvedgaard, 2008, p. 11). While for some it may be difficult to show proper respect for the differences in marriage practices and to fully comprehend how the standard definition of a domestic unit that does not include a husband or father could exist, these are important distinctions remain. Interactions by an outsider with beliefs that differ from Nayar gender relations and beliefs could easily produce criticisms or a sense of condemnation which could quickly derail otherwise honest attempts at gaining progress or cooperation. It has been recognized however that the influence of British colonization and the exposing of criticisms and by force that the matrilineal change to patrilineal form of family organization has been made. Beliefs and Values Over thousands of years of considerable influence by mainstream religious faith denominations such as Christianity, Judaism, and Hinduism, the Nayar have been substantially un-phased in adopting one of the recognized religions. Evidence of the lack of adoption of a primary religion by the Nayar is stated as Nothing shows so much the extreme persistence of primitive culture, even in the face of higher civilising agencies, than the wide and almost universal acceptance of spirit-worship, and the almost entire absence of religious life among the Nayars after at least twenty centuries of contact with Hinduism Panikkar, (1918), p.277. While the Nayar do use Hindu temples for worship and ceremonies, the nature of these particular practices are not recognized under any Hindu creed or other religion for that matter. The Nayar belief in magic and spirit worship continues although they are recognized leaders in literature and music within their culture and subsequently would not be considered uncivilized. Another characteristic of the Nayar people is where they fit within a caste society. A caste is an endogamous social grouping into which a person is born and within which a person remains throughout his or her lifetime. It is an ascribed position. (Nowak, et al., 2010, ch 7.8, n.p.). Within these groupings, marriages and other interactions which were tightly controlled even forbid physical touch across caste. With the capitalistic evolution and exposure to western culture, the adherence too many of the cross-caste practices continue to see change. The impact on discussions or considerations concerning life, business or religion with Nayar people considering both the likely absence of common religious beliefs and belief in magic and spirit worship could be significant. Consider a Christian believer entering into discussion with a Nayar community by condemning Nayar core religious beliefs in hopes of collecting contributions for acquiring land for a new church. In this example, it is unlikely this approach would succeed given criticism of beliefs as a basis for support. If religious beliefs vary as significantly as I have described, what is valued is also in conflict. These differences would then become obstacles in coming together towards common goals if not taken into consideration prior to presenting a position introducing mutually beneficial outcomes in which both parties increase items or results of value. Conclusion The Nayar depended largely on rice for food and to a lesser extent vegetables, fish, and poultry. The formation and growth of families was largely relative to the amount of land they owned and the class of house. The ownership or family structure that developed as a result was more of a community or corporate type of ownership model which was significantly linked to the women and her side of the family in years past. The Nayar are heavily involved in politics and other forms of industrialized production observable by the number of local printing businesses while continuing their tradition of agriculture. In many ways, the Nayar people and culture has adopted many aspects of American and European culture. By gaining a better understanding of the Nayar political organizations, gender relations, and beliefs and values, people from other cultures will better understand and appreciate the cultural differences. This enhanced awareness will be beneficial in helping to offer solutions to problems in government, business growth, housing, and as other forms of industry are introduced or sought out.

Anxiety Disorders :: essays research papers

Anxiety Disorders Anxiety is a feeling of tension associated with a sense of threat of danger when the source of the danger is not known. In comparison, fear is a feeling of tension that is associated with a known source of danger. I believe it is normal for us to have some mild anxiety present in our daily lives. Everyday that I can think of I have some kind of anxiety though out that day. Anxiety warns us and enables us to get ready for the ‘fight or flight’ response. However, heightened anxiety is emotionally painful. It disrupts a person's daily functioning. Anxiety can be seen with several other emotional disorders including the following: Acute Stress Disorder Panic Attack Agoraphobia Phobia Anxiety Disorder Due to Medical Condition Post-traumatic Stress Disorder Generalized Anxiety Disorder Substance-Induced Anxiety Disorder Obsessive-Compulsive Disorder There are many characteristics associated with anxiety. Frequently, people with anxiety experience tightness in their chest, a racing or pounding heart, and a pit in their stomach. Anxiety causes some people to get a headache, to sweat, and even make them have the urge to urinate. Severe anxiety, which can be described as an episode of terror, is referred to as a panic attack. Panic attacks can be extremely frightening. People who experience panic attacks over a prolonged time period may become victims of agoraphobia, which is a psychiatric disorder that is closely associated with the panic disorder. Patients with Agoraphobia avoid certain places or situations such as airplanes, crowded theaters, a grocery store or anyplace from which escape might be difficult. It is said that Agoraphobia can be so severe that it has made certain individuals housebound.   Ã‚  Ã‚  Ã‚  Ã‚  Some people argue that there is a genetic basis for these anxiety disorders. Research shows that there is strong evidence for a genetic basis for anxiety. If a person has anxiety, more than ten percent of his or her relatives will also suffer form some form of anxiety if not the same form that they have.   Ã‚  Ã‚  Ã‚  Ã‚  It has been found that anxiety disorder affect males and females differently. Females are known to be twice as likely to suffer from anxiety than males. On the other hand, an equal number of males and females are both seen for the treatment of their anxiety.   Ã‚  Ã‚  Ã‚  Ã‚   The ages that the people have anxiety attacks vary but, anxiety problems commonly begin when people are in their twenty’s. This is something really great to know when you are only a year a way from being twenty.